Nature Communications (May 2021)

Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

  • Liyun Luo,
  • Zhijie Zhang,
  • Ni Qiu,
  • Li Ling,
  • Xiaoting Jia,
  • Ying Song,
  • Hongsheng Li,
  • Jiansheng Li,
  • Hui Lyu,
  • Hao Liu,
  • Zhimin He,
  • Bolin Liu,
  • Guopei Zheng

DOI
https://doi.org/10.1038/s41467-021-23052-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Resistance to Herceptin represents a major challenge for successful treatment of HER2-positive breast cancer. Here, the authors demonstrate that the activation of the IGF2/IRS1 signal caused by disruption of a negative feedback loop between FOXO3a-miR-128/miR-30/miR-193 induces Herceptin resistance.