Nature Communications (May 2021)
IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques
- Justin Harper,
- Nicolas Huot,
- Luca Micci,
- Gregory Tharp,
- Colin King,
- Philippe Rascle,
- Neeta Shenvi,
- Hong Wang,
- Cristin Galardi,
- Amit A. Upadhyay,
- Francois Villinger,
- Jeffrey Lifson,
- Guido Silvestri,
- Kirk Easley,
- Beatrice Jacquelin,
- Steven Bosinger,
- Michaela Müller-Trutwin,
- Mirko Paiardini
Affiliations
- Justin Harper
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Nicolas Huot
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Luca Micci
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Gregory Tharp
- Nonhuman Primate Genomics Core, Yerkes National Primate Research Center, Emory University
- Colin King
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Philippe Rascle
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Neeta Shenvi
- Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University
- Hong Wang
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Cristin Galardi
- UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill
- Amit A. Upadhyay
- Nonhuman Primate Genomics Core, Yerkes National Primate Research Center, Emory University
- Francois Villinger
- Department of Biology, New Iberia Research Center, University of Louisiana at Lafayette
- Jeffrey Lifson
- AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research
- Guido Silvestri
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Kirk Easley
- Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University
- Beatrice Jacquelin
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Steven Bosinger
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Michaela Müller-Trutwin
- Institut Pasteur, Unité HIV, Inflammation et Persistance
- Mirko Paiardini
- Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- DOI
- https://doi.org/10.1038/s41467-021-23189-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Infection of African green monkeys with SIV is associated with reduced pathogenicity. Here the authors explore the requirement of differentiated NK cell populations in a pathogenic Rhesus macaque model of SIV infection and show administration of IL-21 and IFNα rescues terminally differentiated NK cells, similarly to what found in African green monkeys, and limits the SIV reservoir in antiretroviral therapy treated macaques.
