Nature Communications (Oct 2021)

Theory and simulations of condensin mediated loop extrusion in DNA

  • Ryota Takaki,
  • Atreya Dey,
  • Guang Shi,
  • D. Thirumalai

DOI
https://doi.org/10.1038/s41467-021-26167-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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How chromosomes, which are polymers with nearly billion base pairs, are packaged in the restricted nuclear volume is not well understood. Here, the authors combine polymer physics, nonequilibrium fluctuation theorem, and simulations to quantitatively predict the force-dependent velocity and step-size distribution of condensin, which facilitates the folding of chromosomes by loop extrusion.