Factors Affecting the Left Ventricular Mass Index in Children with Predialysis Chronic Renal Disease

Abstract

INTRODUCTION: We aimed to investigate the clinical, and laboratory factors that may effect the left ventricular mass index in children with stage predialysis chronic renal disease. METHODS: Children with predialysis chronic renal disease consisted the study group. The weight, height, renal diagnosis and follow-up duration were retrieved from medical records. Instantaneous and ambulatory blood pressure measurements were performed. Laboratory tests were performed. The left ventricular mass index was calculated based on the echocardiographic measurements. Frequency of hypertension was calculated, and the correlation between the clinical and laboratory parameters and the left ventricular mass index was investigated.ss index was investigated. RESULTS: Mean left ventricular mass index was 48.8+-12.74 g/m2.7, and left ventricular hypertrophy was detected in 16 (76.1%) patients. Hypertension was detected in 5 (23.8%) patients by instantaneous measurements. However, ambulatory measurements showed systolic and diastolic hypertension in 6 (28.6%) and only diastolic hypertension in 2 (9.5%) patients. A positive and significant correlation was detected between left ventricular mass index and relative body mass index, mean night diastolic blood pressure, night diastolic load and cholesterol level (p<0.05). Also a negative significant correlation between albumin and hemoglobin was detected (p<0.05). DISCUSSION AND CONCLUSION: The results of our study indicate that in predialysis children; ambulatory blood pressure measurement is superior to instantaneous measurements in prediction of left ventricular hypertrophy, and the left ventricular mass index significantly correlates with hemoglobin, cholesterol and albumin levels in addition to blood pressure parameters.

Keywords

• children
• hypertension
• left ventricular hypertrophy
• predialysis chronic renal disease