External genital tumors in women: role of differentiation, localization and histological types for predicting long-term survival value

Abstract

Purpose of the study was to investigate the role of the tumor degree, localization and histological type of tumor at the level of long-term survival by 25-year retrospective observation in women with external genitalia cancer. Materials and methods. 557 medical records of patients treated in National Cancer Institute have been analyzed during the period of 1993–2018 years. Impact of the differentiation degree, localization and histological type on the long-term survival value has been evaluated. Results. It has been proved that the long-term survival value decreased by 27.3% during transition from high (G3) to intermediate (G2) tumor grade, by 10.8% during transition from intermediate (G2) to low (G1) tumor grade. The overall level of 25-year survival retrospectively constituted 45.0% with G3 tumor grade, 31.0% with G2, and 26.0% with G1 tumor grade (p <0.05). The highest mortality has been demonstrated with total affection (66.7%), as well as with lesions of several zones (80.9%). The multiple Kaplan-Meier survival analysis showed that the most unfavorable localization was the area of labia minora, where the probability of survival at 25-year-long observation was 6.0% versus 23.0% for the primary tumor localization in the area of labia majora, and versus 35.0% in the vulvar region localization. Conclusion. The highest rates of cancer mortality are verified in non-differentiated forms of tumor (100.0%) and for sarcoma (63.6%) depending on the morphological form of primary tumor. Mortality rate was more than 50.0% for all forms of squamous cell cancer. Carcinoma and adenocarcinoma with a level of mortality by 20.6 % and 21.4% respectively were more favorable compared to the other morphological forms.

Keywords

• external genital tumors
• survival value
• differentiation degree
• histological type