Nature Communications (Aug 2019)

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

  • Leslie Kirby,
  • Jing Jin,
  • Jaime Gonzalez Cardona,
  • Matthew D. Smith,
  • Kyle A. Martin,
  • Jingya Wang,
  • Hayley Strasburger,
  • Leyla Herbst,
  • Maya Alexis,
  • Jodi Karnell,
  • Todd Davidson,
  • Ranjan Dutta,
  • Joan Goverman,
  • Dwight Bergles,
  • Peter A. Calabresi

DOI
https://doi.org/10.1038/s41467-019-11638-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 20

Abstract

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In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in cell culture and in an animal model of MS.