Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases

Marie C. Sadler; Chiara Auwerx; Kaido Lepik; Eleonora Porcu; Zoltán Kutalik

doi:10.1038/s41467-022-35196-3

Nature Communications (Dec 2022)

Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases

Marie C. Sadler,
Chiara Auwerx,
Kaido Lepik,
Eleonora Porcu,
Zoltán Kutalik

Affiliations

Marie C. Sadler: University Center for Primary Care and Public Health
Chiara Auwerx: University Center for Primary Care and Public Health
Kaido Lepik: University Center for Primary Care and Public Health
Eleonora Porcu: University Center for Primary Care and Public Health
Zoltán Kutalik: University Center for Primary Care and Public Health

DOI: https://doi.org/10.1038/s41467-022-35196-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

The mechanism by which DNA methylation might affect complex traits is not well understood. Here, the authors use Mendelian randomization to reveal a substantial role of transcript levels in mediating DNA methylation effects on complex traits and diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal