The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

Abstract

If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1 −/− and Msh5 −/− oocytes.