Assessment of Mean Platelet Volume in Type 2 Diabetes Mellitus and Prediabetes

Abstract

Introduction: Platelet functions have important roles in the development of vascular complications in diabetic patients. Increased activity has been noted in Platelets with increased volume when compared to smaller ones, thus highlighting the utility of Mean platelet volume as a marker of platelet activity. Aim: To evaluate MPV in patients with type II DM in comparison with a healthy control group and prediabetes group. 1. To study the correlation between MPV and vascular complications. 2. To understand the association of MPV with fasting blood glucose levels and duration of disease. Settings and Design: Descriptive and prospective study. Materials and Methods: A total of 77 patients with type II DM, 25 prediabetes subjects, and 38 healthy subjects attending a teaching hospital of Bangalore constituted the study population. The study subjects were evaluated by performing Complete blood count including MPV, Fasting Blood Glucose levels and Lipid profile. The diabetic subjects were interviewed for duration of disease and examined for presence of microvascular and macrovascular complications apart from noting the HbA1C levels. Mean platelet volume was compared between diabetic patients, prediabetes and healthy counterparts. Within the diabetic group, MPV was compared between this and without vascular complications. The exclusion criteria employed in the study was subjects with anaemia (Hb<11g/dl for females and Hb<12g/dl for males) and thrombocytopenia (<1.5 lakh/μL). Statistical Analysis Used: Statistical evaluation was performed using Pearson correlation test (r value as the coefficient) from which the p value was calculated. Data was expressed as mean +/- standard deviation. A p-value <0.05 was considered statistically significant. Results: MPV of diabetic patients was not significantly different when compared to prediabetes and non-diabetic individuals. Similarly, the MPV had no significant relation to FBS, PPBS, HbA1c and Body mass index. MPV had an inverse relationship with the platelet count. Conclusion: MPV of diabetic patients was not significantly different when compared to prediabetes and non-diabetic individuals. Though the MPV in Diabetics with complications was higher than those without complications, it was not statistically significantly. Further studies are needed to evaluate the utility of MPV in Diabetes Mellitus.

Keywords

• platelet indices
• vascular complications in diabetes mellitus