Nature Communications (Nov 2016)

REST regulation of gene networks in adult neural stem cells

  • Shradha Mukherjee,
  • Rebecca Brulet,
  • Ling Zhang,
  • Jenny Hsieh

DOI
https://doi.org/10.1038/ncomms13360
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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The transcription factor REST plays a crucial role in maintaining the adult neural stem cell pool. To better understand how REST maintains quiescence in neural progenitors, the authors use ChIP-seq and RNA-seq and find that REST regulates represses ribosome biogenesis, cell cycle and neuronal genes.