The Tuberculosis Sentinel Research Network (TB-SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southeast Asia and Latin America
Eugene Messou,
Marcel Yotebieng,
Lukas Fenner,
Helen Byakwaga,
Stephany N Duda,
Kara Wools-Kaloustian,
Marie Ballif,
Timothy R Sterling,
Denise Evans,
Annette H Sohn,
Carolyn Bolton-Moore,
Armel Poda,
Olivier Marcy,
Neelima Navuluri,
Nathalie De Castro,
Leslie A Enane,
Thida Chanyachukul,
Nana Mbonze,
LaQuita R McDade,
Marina Cruvinel Figueiredo,
Jeremy Ross,
Lameck Diero,
Robert Akpata,
Natalia Zotova,
Aimee Freeman,
Marie Flore Pierre,
Dhanushi Rupasinghe,
Martine Tabala,
Robin Huebner
Affiliations
Eugene Messou
Centre de Prise en Charge de Recherche et de Formation (Aconda-CePReF), Abidjan, Côte d`Ivoire
Marcel Yotebieng
Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
Lukas Fenner
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
Helen Byakwaga
Mbarara University of Science and Technology Faculty of Medicine, Mbarara, Uganda
Stephany N Duda
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Kara Wools-Kaloustian
Indiana University Center for Global Health Equity, Indianapolis, Indiana, USA
Marie Ballif
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
Timothy R Sterling
Vanderbilt Tuberculosis Center, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Denise Evans
Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Annette H Sohn
TREAT Asia/amfAR – The Foundation for AIDS Research, Bangkok, Thailand
Carolyn Bolton-Moore
Center for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia
Armel Poda
Centre Hospitalier Universitaire Sourô Sanou, Bobo Dioulasso, Burkina Faso
Olivier Marcy
Université de Bordeaux, Bordeaux, France
Neelima Navuluri
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
Nathalie De Castro
Université de Bordeaux, Bordeaux, France
Leslie A Enane
The Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Thida Chanyachukul
TREAT Asia/amfAR – The Foundation for AIDS Research, Bangkok, Thailand
Nana Mbonze
Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
LaQuita R McDade
Vanderbilt Institute of Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Marina Cruvinel Figueiredo
Vanderbilt Tuberculosis Center, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Jeremy Ross
TREAT Asia/amfAR – The Foundation for AIDS Research, Bangkok, Thailand
Lameck Diero
Department of Medicine, Moi University College of Health Sciences, Eldoret, Kenya
Robert Akpata
Université de Bordeaux, Bordeaux, France
Natalia Zotova
Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
Aimee Freeman
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Marie Flore Pierre
The Haitian Group for the Study of Kaposi’s Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti
Dhanushi Rupasinghe
The Kirby Institute, UNSW, Sydney, New South Wales, Australia
Martine Tabala
Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
Robin Huebner
Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Introduction Tuberculosis (TB) is a leading infectious cause of death globally. It is the most common opportunistic infection in people living with HIV, and the most common cause of their morbidity and mortality. Following TB treatment, surviving individuals may be at risk for post-TB lung disease. The TB Sentinel Research Network (TB-SRN) provides a platform for coordinated observational TB research within the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium.Methods and analysis This prospective, observational cohort study will assess treatment and post-treatment outcomes of pulmonary TB (microbiologically confirmed or clinically diagnosed) among 2600 people aged ≥15 years, with and without HIV coinfection, consecutively enrolled at 16 sites in 11 countries, across 6 of IeDEA’s global regions. Data regarding clinical and sociodemographic factors, mental health, health-related quality of life, pulmonary function, and laboratory and radiographic findings will be collected using standardised questionnaires and data collection tools, beginning from the initiation of TB treatment and through 12 months after the end of treatment. Data will be aggregated for proposed analyses.Ethics and dissemination Ethics approval was obtained at all implementing study sites, including the Vanderbilt University Medical Center Human Research Protections Programme. Participants will provide informed consent; for minors, this includes both adolescent assent and the consent of their parent or primary caregiver. Protections for vulnerable groups are included, in alignment with local standards and considerations at sites. Procedures for requesting use and analysis of TB-SRN data are publicly available. Findings from TB-SRN analyses will be shared with national TB programmes to inform TB programming and policy, and disseminated at regional and global conferences and other venues.
