A young child with HIV and unsteady gait: A case report
Nadine Yazbeck,
Yolla Youssef,
Rima Hanna-Wakim
Affiliations
Nadine Yazbeck
Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon
Yolla Youssef
Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon; Division of Pediatric Infectious Diseases, Department of Pediatrics and Adolescent Medicine, Lebanon; Center for Infectious Diseases Research, American University of Beirut Medical Center, Beirut, Lebanon
Rima Hanna-Wakim
Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon; Division of Pediatric Infectious Diseases, Department of Pediatrics and Adolescent Medicine, Lebanon; Center for Infectious Diseases Research, American University of Beirut Medical Center, Beirut, Lebanon; Corresponding author at: American University of Beirut, Riad El Solh 110 72020, Beirut, Lebanon.
Background: We would like to raise awareness about the toxicities related to the added excipients present in the oral solution of Liponavir/ritonavir in particular alcohol and propylene glycol. Case presentation: In this case report, we describe an 18 month-old child with a newly diagnosed HIV infection on antiretroviral therapy (ART). She developed shortly after starting the ART unsteady gait and imbalance. Conclusions: The excipient-excipient interaction in Lopinavir/ritonavir may contribute to major toxicities not only in premature neonates and infants; but also in older children specifically from Asian ethnicity. Keywords: HIV, Lopinavir-ritonavir, Unsteady gait
