Haematologica (Dec 2008)

Risk factors and decision criteria for intensive chemotherapy in older patients with acute myeloid leukemia

  • Jean-Valère Malfuson,
  • Anne Etienne,
  • Pascal Turlure,
  • Thierry de Revel,
  • Xavier Thomas,
  • Nathalie Contentin,
  • Christine Terré,
  • Sophie Rigaudeau,
  • Dominique Bordessoule,
  • Norbert Vey,
  • Claude Gardin,
  • Hervé Dombret,
  • for the Acute Leukemia French Association (ALFA)

DOI
https://doi.org/10.3324/haematol.13309
Journal volume & issue
Vol. 93, no. 12

Abstract

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Background There is a need for standardization of treatment decisions in older patients with acute myeloid leukemia. The aim of the present study was to analyze the decisional value of poor risk factors in 416 elderly patients treated in the ALFA-9803 trial in order to derive a decisional index.Design and Methods Standard multivariate analysis was used to identify risk factors for overall survival. Risk factors were then considered as good decision tools if associated with a frequency >10% and a false positive rate