Frontiers in Medicine (Apr 2022)
Prognostic-Related Metabolic Score for Survival Prediction in Early-Stage Endometrioid Endometrial Cancer: A Multi-Center and Retrospective Study
- Zizhuo Wang,
- Zizhuo Wang,
- Kun Song,
- Jingbo Liu,
- Jingbo Liu,
- Qing Zhang,
- Chuyao Zhang,
- Beibei Wang,
- Beibei Wang,
- Yu Fu,
- Yu Fu,
- Yu Wang,
- Shuzhong Yao,
- Congjian Xu,
- Min Xia,
- Ge Lou,
- Jihong Liu,
- Bei Lin,
- Jianliu Wang,
- Weidong Zhao,
- Jieqing Zhang,
- Wenjun Cheng,
- Hongyan Guo,
- Ruixia Guo,
- Fengxia Xue,
- Xipeng Wang,
- Lili Han,
- Xia Zhao,
- Xiaomao Li,
- Ping Zhang,
- Jianguo Zhao,
- Jianguo Zhao,
- Jianguo Zhao,
- Jiezhi Ma,
- Qin Yao,
- Wenting Li,
- Wenting Li,
- Xiaohang Yang,
- Xiaohang Yang,
- Yong Fang,
- Yong Fang,
- Gang Chen,
- Gang Chen,
- Kezhen Li,
- Kezhen Li,
- Yuanming Shen,
- Chaoyang Sun,
- Chaoyang Sun,
- Beihua Kong
Affiliations
- Zizhuo Wang
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Zizhuo Wang
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Kun Song
- Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
- Jingbo Liu
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jingbo Liu
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Qing Zhang
- Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
- Chuyao Zhang
- Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
- Beibei Wang
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Beibei Wang
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yu Fu
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yu Fu
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yu Wang
- Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
- Shuzhong Yao
- Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Congjian Xu
- Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
- Min Xia
- Department of Obstetrics and Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
- Ge Lou
- Department of Gynecology Oncology, Harbin Medical University Cancer Hospital, Harbin, China
- Jihong Liu
- Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
- Bei Lin
- 0Department of Obstetrics and Gynecology, ShengJing Hospital of China Medical University, Shenyang, China
- Jianliu Wang
- 1Peking University People’s Hospital, Beijing, China
- Weidong Zhao
- 2Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
- Jieqing Zhang
- 3Department of Gynecologic Oncology, Guangxi Medical University Cancer Hospital, Nanning, China
- Wenjun Cheng
- 4The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
- Hongyan Guo
- 5Peking University Third Hospital, Beijing, China
- Ruixia Guo
- 6Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Fengxia Xue
- 7Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China
- Xipeng Wang
- 8Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Lili Han
- 9Department of Gynecology, People’s Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China
- Xia Zhao
- 0Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, China
- Xiaomao Li
- 1Department of Obstetrics and Gynecology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Ping Zhang
- 2Department of Gynecology, The Second Hospital of Shandong University, Jinan, China
- Jianguo Zhao
- 3Department of Gynecologic Oncology, Tianjin Central Hospital of Gynecology and Obstetrics, Affiliated Hospital of Nankai University, Tianjin, China
- Jianguo Zhao
- 4Tianjin Clinical Research Center for Gynecology and Obstetrics, Tianjin, China
- Jianguo Zhao
- 5Branch of National Clinical Research Center for Gynecology and Obstetrics, Tianjin, China
- Jiezhi Ma
- 6Department of Obstetrics and Gynecology, The Third Xiangya Hospital, Central South University, Changsha, China
- Qin Yao
- 7Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China
- Wenting Li
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Wenting Li
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xiaohang Yang
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xiaohang Yang
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yong Fang
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yong Fang
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Gang Chen
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Gang Chen
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Kezhen Li
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Kezhen Li
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yuanming Shen
- Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
- Chaoyang Sun
- Key Laboratory of the Ministry of Education, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Chaoyang Sun
- Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Beihua Kong
- Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
- DOI
- https://doi.org/10.3389/fmed.2022.830673
- Journal volume & issue
-
Vol. 9
Abstract
ObjectivePatients with endometrial cancer (EC) combined with metabolic syndrome (MetS) have a worse prognosis than those without MetS. This study aimed to investigate whether partial metabolic disorder significantly influenced early-stage endometrioid EC (EEC) survival and searched for a more efficient method to evaluate metabolic status.MethodsThis is a nationwide, multicenter cohort study that included 998 patients with primary early-stage EEC from 2001 to 2018. Patients were divided into different metabolic groups based on the diagnostic criteria of the Chinese Medical Association (CDC). The progression-free survival (PFS) time was compared between various metabolic status. Meanwhile, we established an EC Prognostic-Related Metabolic Score (ECPRM Score) to explore the association of the severity of metabolic status and early-stage EEC PFS. A nomogram was established for predicting PFS, which was externally validated in a testing set that includes 296 patients.ResultsA partial metabolic disorder, as well as MetS, was an independent risk factor of poor survival of patients with early-stage EEC [hazard ratio (HR) = 7.6, 95% CI = 1.01–57.5, p < 0.05]. A high ECPRM Score was associated with lower PFS (HR = 2.1, 95% CI = 1.05–4.0, p < 0.001). The nomogram, in which the ECPRM Score contributed most to the prognosis, exhibited excellent discrimination of survival supported by the internal and external validations. In addition, the calibration curve supports its robust predicting ability.ConclusionEven though they do not meet the criteria of MetS, partial metabolic disorders were also associated with adverse outcomes in early-stage EEC. The ECPRM Score is beneficial for clinicians to evaluate the severity of metabolic abnormalities and guide patients to ameliorate the poor prognosis of metabolic disorders.
Keywords
- metabolic status
- partial metabolic disorders
- early-stage endometrioid endometrial cancer
- progression-free survival time
- ECPRM Score