Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics

Archana Adhikari; Syed Mohammed Basheeruddin Asdaq; Maitham A. Al Hawaj; Manodeep Chakraborty; Gayatri Thapa; Nihar Ranjan Bhuyan; Mohd. Imran; Mohammed Kanan Alshammari; Mohammed M. Alshehri; Aishah Ali Harshan; Abeer Alanazi; Bushra Dhuhayyan Alhazmi; Nagaraja Sreeharsha

doi:10.3390/ph14100970

Pharmaceuticals (Sep 2021)

Anticancer Drug-Induced Cardiotoxicity: Insights and Pharmacogenetics

Archana Adhikari,
Syed Mohammed Basheeruddin Asdaq,
Maitham A. Al Hawaj,
Manodeep Chakraborty,
Gayatri Thapa,
Nihar Ranjan Bhuyan,
Mohd. Imran,
Mohammed Kanan Alshammari,
Mohammed M. Alshehri,
Aishah Ali Harshan,
Abeer Alanazi,
Bushra Dhuhayyan Alhazmi,
Nagaraja Sreeharsha

Affiliations

Archana Adhikari: Pharmacology Department, Himalayan Pharmacy Institute Majhitar, Rangpo 737136, Sikkim, India
Syed Mohammed Basheeruddin Asdaq: Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi Arabia
Maitham A. Al Hawaj: Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Hofuf 31982, Saudi Arabia
Manodeep Chakraborty: Pharmacology Department, Himalayan Pharmacy Institute Majhitar, Rangpo 737136, Sikkim, India
Gayatri Thapa: Pharmacology Department, Himalayan Pharmacy Institute Majhitar, Rangpo 737136, Sikkim, India
Nihar Ranjan Bhuyan: Department of Pharmaceutical Analysis, Himalayan Pharmacy Institute, Majhitar, Rangpo 737136, Sikkim, India
Mohd. Imran: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia
Mohammed Kanan Alshammari: Department of Pharmaceutical Care, Rafha Central Hospital, North Zone, Rafha 91911, Saudi Arabia
Mohammed M. Alshehri: Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh 11426, Saudi Arabia
Aishah Ali Harshan: Department of Pharmaceutical Care, Northern Area Armed Forces Hospital, King Khalid Military City Hospital, Hafr Al-Batin 39745, Saudi Arabia
Abeer Alanazi: Department of Pharmaceutical Care, First Health Cluster in Eastern Province, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia
Bushra Dhuhayyan Alhazmi: Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia
Nagaraja Sreeharsha: Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa-31982, Saudi Arabia

DOI: https://doi.org/10.3390/ph14100970
Journal volume & issue: Vol. 14, no. 10
p. 970

Abstract

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The advancement in therapy has provided a dramatic improvement in the rate of recovery among cancer patients. However, this improved survival is also associated with enhanced risks for cardiovascular manifestations, including hypertension, arrhythmias, and heart failure. The cardiotoxicity induced by chemotherapy is a life-threatening consequence that restricts the use of several chemotherapy drugs in clinical practice. This article addresses the prevalence of cardiotoxicity mediated by commonly used chemotherapeutic and immunotherapeutic agents. The role of susceptible genes and radiation therapy in the occurrence of cardiotoxicity is also reviewed. This review also emphasizes the protective role of antioxidants and future perspectives in anticancer drug-induced cardiotoxicities.

Published in Pharmaceuticals

ISSN: 1424-8247 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceuticals/

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