Isoniazid-induced acute pancreatitis in a child with tuberculous meningitis

Abstract

Drug-related acute pancreatitis is uncommon in children and is mostly caused due to valproic acid, l-asparaginase, prednisone, and 6-mercaptopurine. Anti-tuberculous drugs causing pancreatitis are rare. We present a 3-year-old girl with tuberculous meningitis who developed isoniazid (INH)-induced pancreatitis. She has persistent vomiting in spite of omission of steroids and ultrasound showed bulky pancreas with high serum amylase. Her vomiting subsided with the omission of INH.

Keywords

• Anti-tuberculous therapy
• isoniazid
• pancreatitis
• vomiting