Association Between 50 bp Insertion/Deletion Polymorphism in Promoter of the Superoxide Dismutase-1 and Temperament

Abstract

Introduction: Temperament (mizaj) plays an important role in society’s general health as well as in diagnosis and treatment of diseases. Despite its effectiveness, the mechanisms of temperament-dependent treatment in practical Iranian Traditional Medicine (ITM) has not been well understood yet. This study aimed to evaluate the association between the temperament and superoxide dismutase-1 (SOD1) polymorphism. Methods: The study was carried out on healthy blood donors. All participants were from Fars province, southern Iran. To determine the participants’ temperaments, a self-reported identification scale was used. Two hundred eighty males with any of 4 simple temperaments (Warm, Cold, Moist, and Dry) were included. The SOD1 genotypes were determined using a polymerase chain reaction (PCR)-based method. Multinomial logistic regression was used to calculate odds ratios (ORs) and 95% CI for the association of temperament with SOD1 polymorphism. Results: No association was found between the insertion/deletion (Ins/Del) polymorphism of SOD1 and each of the temperament groups. Conclusion: The results of this study indicated that the temperament is not affected by the Ins/ Del polymorphism of SOD1. Further research with larger samples and with other genes of antioxidant system is recommended.

Keywords

• Temperament
• Superoxide dismutase-1
• Polymorphism