LMO7 deficiency reveals the significance of the cuticular plate for hearing function

Ting-Ting Du; James B. Dewey; Elizabeth L. Wagner; Runjia Cui; Jinho Heo; Jeong-Jin Park; Shimon P. Francis; Edward Perez-Reyes; Stacey J. Guillot; Nicholas E. Sherman; Wenhao Xu; John S Oghalai; Bechara Kachar; Jung-Bum Shin

doi:10.1038/s41467-019-09074-4

Nature Communications (Mar 2019)

LMO7 deficiency reveals the significance of the cuticular plate for hearing function

Ting-Ting Du,
James B. Dewey,
Elizabeth L. Wagner,
Runjia Cui,
Jinho Heo,
Jeong-Jin Park,
Shimon P. Francis,
Edward Perez-Reyes,
Stacey J. Guillot,
Nicholas E. Sherman,
Wenhao Xu,
John S Oghalai,
Bechara Kachar,
Jung-Bum Shin

Affiliations

Ting-Ting Du: Department of Neuroscience, University of Virginia
James B. Dewey: Caruso Department of Otolaryngology-Head and Neck Surgery, University of Southern California
Elizabeth L. Wagner: Department of Neuroscience, University of Virginia
Runjia Cui: National Institute for Deafness and Communications Disorders, National Institute of Health
Jinho Heo: Center for Cell Signaling and Department of Microbiology, Immunology and Cancer Biology, University of Virginia
Jeong-Jin Park: Biomolecular Analysis Facility, University of Virginia
Shimon P. Francis: Department of Neuroscience, University of Virginia
Edward Perez-Reyes: Department of Pharmacology, University of Virginia
Stacey J. Guillot: Advanced Microscopy core, University of Virginia
Nicholas E. Sherman: Biomolecular Analysis Facility, University of Virginia
Wenhao Xu: Genetically Engineered Murine Model (GEMM) core, University of Virginia
John S Oghalai: Caruso Department of Otolaryngology-Head and Neck Surgery, University of Southern California
Bechara Kachar: National Institute for Deafness and Communications Disorders, National Institute of Health
Jung-Bum Shin: Department of Neuroscience, University of Virginia

DOI: https://doi.org/10.1038/s41467-019-09074-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. In this study, authors describe the discovery of a hair cell protein called LIM only protein 7, which is localized in the cuticular plate and the cell junction and may play a role in age-related deafness.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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