Molecules (Feb 2004)

Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

  • Hussein F.. Zohdi,
  • Ayman M. Saleh,
  • Ibrahim M. Abdou

DOI
https://doi.org/10.3390/90300109
Journal volume & issue
Vol. 9, no. 3
pp. 109 – 116

Abstract

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2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.

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