Subversion of GBP-mediated host defense by E3 ligases acquired during Yersinia pestis evolution

Shiyang Cao; Yang Jiao; Wei Jiang; Yarong Wu; Si Qin; Yifan Ren; Yang You; Yafang Tan; Xiao Guo; Hongyan Chen; Yuan Zhang; Gengshan Wu; Tong Wang; Yazhou Zhou; Yajun Song; Yujun Cui; Feng Shao; Ruifu Yang; Zongmin Du

doi:10.1038/s41467-022-32218-y

Nature Communications (Aug 2022)

Subversion of GBP-mediated host defense by E3 ligases acquired during Yersinia pestis evolution

Shiyang Cao,
Yang Jiao,
Wei Jiang,
Yarong Wu,
Si Qin,
Yifan Ren,
Yang You,
Yafang Tan,
Xiao Guo,
Hongyan Chen,
Yuan Zhang,
Gengshan Wu,
Tong Wang,
Yazhou Zhou,
Yajun Song,
Yujun Cui,
Feng Shao,
Ruifu Yang,
Zongmin Du

Affiliations

Shiyang Cao: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Yang Jiao: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Wei Jiang: National Institute of Biological Sciences
Yarong Wu: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Si Qin: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Yifan Ren: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Yang You: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Yafang Tan: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Xiao Guo: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Hongyan Chen: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Yuan Zhang: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Gengshan Wu: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Tong Wang: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Yazhou Zhou: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Yajun Song: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Yujun Cui: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Feng Shao: National Institute of Biological Sciences
Ruifu Yang: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Zongmin Du: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology

DOI: https://doi.org/10.1038/s41467-022-32218-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Guanylate-binding proteins (GBPs) recognize pathogen containing vacuoles, leading to lysis of this intracellular niche and induction of inflammasomes. Here, Cao et al. show that Y. pestis, the causative agent of plague, secret two functionally redundant E3 ligase, YspE1 and YspE2, into the host’s cytosol to ubiquitinate multiple GBPs for proteasomal degradation to subvert host immune defense. This capability appears to be newly acquired by Y. pestis during evolution, since its closely related progenitor Y. pseudotuberculosis is unable to do so.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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