Nature Communications (Oct 2022)

Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model

  • Hannah Drew Rickner,
  • Lulu Jiang,
  • Rui Hong,
  • Nicholas K. O’Neill,
  • Chromewell A. Mojica,
  • Benjamin J. Snyder,
  • Lushuang Zhang,
  • Dipan Shaw,
  • Maria Medalla,
  • Benjamin Wolozin,
  • Christine S. Cheng

DOI
https://doi.org/10.1038/s41467-022-34005-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 22

Abstract

Read online

Single cell RNA-sequencing of the AstTau neuron-asteroid tau assembloid model reveals excitatory neuron inflammatory signatures and an astrocytic heat shock response similar to that occurring in the brains of individuals with tauopathies, which can be ameliorated with a neuroprotective HSP90 inhibitor.