Frontiers in Immunology (Jul 2020)
Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids
- Lisa F. Stinson,
- Lisa F. Stinson,
- Melvin C. L. Gay,
- Melvin C. L. Gay,
- Petya T. Koleva,
- Petya T. Koleva,
- Merete Eggesbø,
- Merete Eggesbø,
- Christine C. Johnson,
- Christine C. Johnson,
- Ganesa Wegienka,
- Ganesa Wegienka,
- Elloise du Toit,
- Elloise du Toit,
- Naoki Shimojo,
- Naoki Shimojo,
- Daniel Munblit,
- Daniel Munblit,
- Daniel Munblit,
- Dianne E. Campbell,
- Dianne E. Campbell,
- Susan L. Prescott,
- Susan L. Prescott,
- Donna T. Geddes,
- Donna T. Geddes,
- Anita L. Kozyrskyj,
- Anita L. Kozyrskyj
Affiliations
- Lisa F. Stinson
- School of Molecular Sciences, University of Western Australia, Perth, WA, Australia
- Lisa F. Stinson
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Melvin C. L. Gay
- School of Molecular Sciences, University of Western Australia, Perth, WA, Australia
- Melvin C. L. Gay
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Petya T. Koleva
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Petya T. Koleva
- Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
- Merete Eggesbø
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Merete Eggesbø
- Department of Environmental Exposure and Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
- Christine C. Johnson
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Christine C. Johnson
- Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, United States
- Ganesa Wegienka
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Ganesa Wegienka
- Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, United States
- Elloise du Toit
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Elloise du Toit
- Division of Medical Microbiology, University of Cape Town, Cape Town, South Africa
- Naoki Shimojo
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Naoki Shimojo
- Department of Pediatrics, Chiba University, Chiba, Japan
- Daniel Munblit
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Daniel Munblit
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
- Daniel Munblit
- Inflammation, Repair and Development Section, National Heart & Lung Institute, Imperial College London, London, United Kingdom
- Dianne E. Campbell
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Dianne E. Campbell
- 0Department of Allergy and Immunology, Children's Hospital at Westmead, University of Sydney, Sydney, NSW, Australia
- Susan L. Prescott
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Susan L. Prescott
- 1The ORIGINS Project, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia
- Donna T. Geddes
- School of Molecular Sciences, University of Western Australia, Perth, WA, Australia
- Donna T. Geddes
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Anita L. Kozyrskyj
- inVIVO Planetary Health of the Worldwide Universities Network (WUN), West New York, NJ, United States
- Anita L. Kozyrskyj
- Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
- DOI
- https://doi.org/10.3389/fimmu.2020.01427
- Journal volume & issue
-
Vol. 11
Abstract
Short chain fatty acids (SFCAs) are microbial metabolites produced in the gut upon fermentation of dietary fiber. These metabolites interact with the host immune system and can elicit epigenetic effects. There is evidence to suggest that SCFAs may play a role in the developmental programming of immune disorders and obesity, though evidence in humans remains sparse. Here we have quantified human milk (HM) SCFA levels in an international cohort of atopic and non-atopic mothers (n = 109). Our results demonstrate that human milk contains detectable levels of the SCFAs acetate, butyrate, and formate. Samples from atopic mothers had significantly lower concentrations of acetate and butyrate than those of non-atopic mothers. HM SCFA levels in atopic and non-atopic women also varied based on maternal country of residence (Australia, Japan, Norway, South Africa, USA). Reduced exposure to HM SCFA in early life may program atopy or overweight risk in breastfed infants.
Keywords
