Langerhans cell histiocytosis in adults: literature review

Abstract

Langerhans cells histiocytosis is a variant of malignant histiocytosis. The course and symptoms vary. patients with localized forms have a better prognosis, because local therapy is effective. patients with multifocal forms of histiocytosis receive systemic drug therapy, which cures some of the patients. This review provides up-to-date data about typical presentation of the organ involvement, diagnosis, course and therapy of various forms of Langerhans cells histiocytosis.

Keywords

• langerhans cell histiocytosis
• pneumothorax
• diabetes insipidus
• cladribine
• vemurafenib
• cobimetinib
• braf
• mek
• mapk