Profile of adult acute cholinesterase inhibitors
substances poisoning – a 30 years analysis
Gazzi Eugen N.,
Sorodoc Victorita,
Jaba Irina M.,
Lionte Catalina,
Bologa Cristina,
Lupusoru Catalina E.,
Lupusoru Raoul,
Sorodoc Laurentiu,
Petris Ovidiu
Affiliations
Gazzi Eugen N.
„Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
and Toxicology Department, School of Medicine „Gr. T. Popa”
University of Medicine and Pharmacy, Iasi, Romania
Sorodoc Victorita
„Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
and Toxicology Department, School of Medicine „Gr. T. Popa”
University of Medicine and Pharmacy, Iasi, Romania
Jaba Irina M.
Pharmacology – Toxicology Department,
Faculty of Medicine, „Gr. T. Popa” University of Medicine
and Pharmacy, Iasi, Romania
Lionte Catalina
„Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
and Toxicology Department, School of Medicine „Gr. T. Popa”
University of Medicine and Pharmacy, Iasi, Romania
Bologa Cristina
„Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
and Toxicology Department, School of Medicine „Gr. T. Popa”
University of Medicine and Pharmacy, Iasi, Romania
Lupusoru Catalina E.
Pharmacology – Toxicology Department,
Faculty of Medicine, „Gr. T. Popa” University of Medicine
and Pharmacy, Iasi, Romania
Lupusoru Raoul
Physiopathology Department, Faculty of Medicine,
„Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Sorodoc Laurentiu
„Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
and Toxicology Department, School of Medicine „Gr. T. Popa”
University of Medicine and Pharmacy, Iasi, Romania
Petris Ovidiu
„Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
and Toxicology Department, School of Medicine „Gr. T. Popa”
University of Medicine and Pharmacy, Iasi, Romania
Objectives: The objective of this study was to assess the pattern and outcome of acute cholinesterase inhibitors substances (CIS) poisoning cases, in a cohort from a regional tertiary care hospital. Methods: cases admitted in the Toxicology Clinic of “Sf. Spiridon” Emergency Clinic Hospital Iasi, Romania between 1983 and 2013 were studied. Results: a total number of 606 patients were included. The reason for exposures was intentional in 70% of cases and the commonest route of poisoning was oral in 92.2%. The highest percent of cases was females (56.4), the age group 20-29 (25.4%) and the majority (66.7%) coming from rural areas, 28.2% being agricultural workers. 36.6% of cases were severe clinical forms. Overall mortality rates were 3.8%, more than half of the death patients (65.2%) had concomitant alcohol intake. It was a significant statistical association between decrease level of serum cholinesterase on admittance and severe forms (p 0.000) and between survival and deaths groups (p 0.000). The pattern of poisoning described by our retrospective study suggests that CIS poisoning are mainly preventable. The main effective goals for prevention are restriction in free accessibility to toxic pesticides, together with sustained efforts in education concerning the life-threatening danger of pesticide poisoning.
