Renin-Secreting Ovarian Adult Granulosa Cell Tumor in a Patient With New-Onset Hypertension and Hypokalemia

Rowan Karaman, MD; Jin Xu, MD; Ross F. Harrison, MD; David M. Kushner, MD; Paul S. Weisman, MD; Yoram Shenker, MD

AACE Clinical Case Reports (Mar 2019)

Renin-Secreting Ovarian Adult Granulosa Cell Tumor in a Patient With New-Onset Hypertension and Hypokalemia

Rowan Karaman, MD,
Jin Xu, MD,
Ross F. Harrison, MD,
David M. Kushner, MD,
Paul S. Weisman, MD,
Yoram Shenker, MD

Affiliations

Rowan Karaman, MD: From the Departments of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Jin Xu, MD: Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Ross F. Harrison, MD: Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
David M. Kushner, MD: Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Paul S. Weisman, MD: Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Yoram Shenker, MD: From the Departments of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.; Address correspondence to Dr. Yoram Shenker, 1685 Highland Avenue, MFCB 4th Floor, Division of Endocrinology, Madison, WI 53705.

Journal volume & issue: Vol. 5, no. 2
pp. e168 – e171

Abstract

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ABSTRACT: Objective: To describe a case of a renin-secreting ovarian tumor, which is a rare cause of hyperreninemia leading to secondary hypertension and hypokalemia.Methods: We present the first case of a patient with a molecularly confirmed renin-secreting ovarian adult granulosa cell tumor.Results: A 31-year-old female presented with hypertension and amenorrhea. She was found to have spontaneous hypokalemia. Computed tomography scan showed a pelvic mass which was resected and found to be a renin-secreting ovarian adult granulosa cell tumor. The hypertension and hypokalemia resolved after the mass was resected.Conclusion: Renin-secreting ovarian adult granulosa cell tumors are rare causes of hyperreninemia leading to hypertension and hypokalemia.Abbreviations: GCT = granulosa cell tumor; RAAS = renin-angiotensin-aldosterone system

Published in AACE Clinical Case Reports

ISSN: 2376-0605 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.journals.elsevier.com/aace-clinical-case-reports

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