Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

Wenjing Yang; Tianming Yu; Xiangsheng Huang; Anthony J. Bilotta; Leiqi Xu; Yao Lu; Jiaren Sun; Fan Pan; Jia Zhou; Wenbo Zhang; Suxia Yao; Craig L. Maynard; Nagendra Singh; Sara M. Dann; Zhanju Liu; Yingzi Cong

doi:10.1038/s41467-020-18262-6

Nature Communications (Sep 2020)

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

Wenjing Yang,
Tianming Yu,
Xiangsheng Huang,
Anthony J. Bilotta,
Leiqi Xu,
Yao Lu,
Jiaren Sun,
Fan Pan,
Jia Zhou,
Wenbo Zhang,
Suxia Yao,
Craig L. Maynard,
Nagendra Singh,
Sara M. Dann,
Zhanju Liu,
Yingzi Cong

Affiliations

Wenjing Yang: Department of Microbiology and Immunology, The University of Texas Medical Branch
Tianming Yu: Department of Microbiology and Immunology, The University of Texas Medical Branch
Xiangsheng Huang: Department of Microbiology and Immunology, The University of Texas Medical Branch
Anthony J. Bilotta: Department of Microbiology and Immunology, The University of Texas Medical Branch
Leiqi Xu: Department of Microbiology and Immunology, The University of Texas Medical Branch
Yao Lu: Department of Microbiology and Immunology, The University of Texas Medical Branch
Jiaren Sun: Department of Microbiology and Immunology, The University of Texas Medical Branch
Fan Pan: Immunology and Hematopoiesis Division, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
Jia Zhou: Chemical Biology Program, Department of Pharmacology and Toxicology, The University of Texas Medical Branch
Wenbo Zhang: Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch
Suxia Yao: Department of Microbiology and Immunology, The University of Texas Medical Branch
Craig L. Maynard: Department of Pathology, University of Alabama at Birmingham
Nagendra Singh: Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Augusta University
Sara M. Dann: Department of Internal Medicine, The University of Texas Medical Branch
Zhanju Liu: Department of Gastroenterology, The Shanghai Tenth People’s Hospital
Yingzi Cong: Department of Microbiology and Immunology, The University of Texas Medical Branch

DOI: https://doi.org/10.1038/s41467-020-18262-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

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Intestinal IL-22 has important regulatory effects on the barrier and intestinal diseases and its production is controlled by the intestinal microbiome. Here the authors show that intestinal immune cell production of IL-22 is regulated by short chain fatty acids via an aryl hydrocarbon receptor and HIF1α-mediated mechanism that protects mice from intestinal inflammation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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