Revista de Ciencias Médicas de Pinar del Río (Dec 2016)
Levels of enzymatic lactate dehydrogenase activity in patients suffering from oral cancer
Abstract
Introduction: in recent years the prevalence of oral cancer has increased, making it necessary to look for tests to establish the early risks of suffering from this disease. There are different cellular and tissue biomarkers that from a molecular perspective provide additional information apart from the clinical examination. Objective: to determine the levels of enzymatic activity of lactate dehydrogenase [LDH] in patients with oral cancer, Pinar del Río 2015-2016. Method: an observational, descriptive and cross-sectional study was carried out in a sample of 60 patients who attended for first time at the consultation of head and neck cancer, III Congreso Cancer Hospital in Pinar del Río, from September 2015 to June 2016. A survey was applied and the data were collected from the clinical histories, determining the levels of enzymatic lactate dehydrogenase activity. Results: 82% of patients were male; the age bracket was 60 years and older, the most representative group (70%); degree-I carcinoma (50%); stage-IV carcinoma (53%) was the most frequent found; 55% showed elevated levels of lactate dehydrogenase. Conclusions: male patients 60 years and older were the most affected by oral cancer. Degree I and stage IV carcinomas resulted in the most frequent lesions. There was a close relationship between the degree and stage of carcinomas and the elevated levels of lactate dehydrogenase in patients included on the study. DeCS: MOUTH CANCER; BIOMARKERS
