Natural product fragment combination to performance-diverse pseudo-natural products

Michael Grigalunas; Annina Burhop; Sarah Zinken; Axel Pahl; José-Manuel Gally; Niklas Wild; Yannik Mantel; Sonja Sievers; Daniel J. Foley; Rebecca Scheel; Carsten Strohmann; Andrey P. Antonchick; Herbert Waldmann

doi:10.1038/s41467-021-22174-4

Nature Communications (Mar 2021)

Natural product fragment combination to performance-diverse pseudo-natural products

Michael Grigalunas,
Annina Burhop,
Sarah Zinken,
Axel Pahl,
José-Manuel Gally,
Niklas Wild,
Yannik Mantel,
Sonja Sievers,
Daniel J. Foley,
Rebecca Scheel,
Carsten Strohmann,
Andrey P. Antonchick,
Herbert Waldmann

Affiliations

Michael Grigalunas: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Annina Burhop: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Sarah Zinken: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Axel Pahl: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
José-Manuel Gally: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Niklas Wild: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Yannik Mantel: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Sonja Sievers: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Daniel J. Foley: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Rebecca Scheel: Technical University Dortmund, Faculty of Chemistry and Inorganic Chemistry
Carsten Strohmann: Technical University Dortmund, Faculty of Chemistry and Inorganic Chemistry
Andrey P. Antonchick: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Herbert Waldmann: Department of Chemical Biology, Max Planck Institute of Molecular Physiology

DOI: https://doi.org/10.1038/s41467-021-22174-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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