NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing

Lingfei Lu; Benhao Li; Suwan Ding; Yong Fan; Shangfeng Wang; Caixia Sun; Mengyao Zhao; Chun-Xia Zhao; Fan Zhang

doi:10.1038/s41467-020-18051-1

Nature Communications (Aug 2020)

NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing

Lingfei Lu,
Benhao Li,
Suwan Ding,
Yong Fan,
Shangfeng Wang,
Caixia Sun,
Mengyao Zhao,
Chun-Xia Zhao,
Fan Zhang

Affiliations

Lingfei Lu: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University
Benhao Li: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University
Suwan Ding: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University
Yong Fan: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University
Shangfeng Wang: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University
Caixia Sun: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University
Mengyao Zhao: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University
Chun-Xia Zhao: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
Fan Zhang: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University

DOI: https://doi.org/10.1038/s41467-020-18051-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Conventional bioluminescence imaging usually operates in the visible region and its performance is limited by strong tissue absorption and scattering. Here, the authors present bioluminescence probes (BPs) with emission in the second near infrared (NIR-II) region, and show the NIR-II-BPs could sensitively recognize tumor metastasis with a high tumor-to-normal tissue ratio.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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