Antioxidant and Cardioprotective Effect of Coconut Water against Doxorubicin Induced Cardiomyopathy

Abstract

Background: Cardiomyopathy is a chronic dis-order affecting the muscle of the heart. It mayresult in to heart failure. Aim: To investigatethe effects of coconut water on antioxidant andcardiac markers on doxorubicin induced cardi-omyopathy in wistar rats. Material and Meth-ods: 21 wistar rats were divided into 3 groupsof 7 rats per group. Group I served as Controlwhile Group II and Group III were administered2.5mg/Kg doxorubicin. Group III in additionwas administered with 3ml of coconut water for28 days. Results: The results obtained showedthat the level of Lactate Dehydrogenase (LDH),Aspartate Aminotransferase (AST) and AlanineAminotransferase were significantly increasedin Group II when compared with the ControlGroup (P<0.05). On the other hand, the levelof antioxidant vitamins C and E were signifi-cantly decreased in Group II when comparedwith the Control Group. However, on the treat-ment with coconut water, the cardiac enzymeswere decreased while antioxidant vitamins im-proved. Conclusion:This could probably implythat coconut water possess beneficial antioxi-dant and cardioprotective potentials

Keywords

• Antioxidants
• Cardioprotective
• Coconut Water
• Doxorubicin.