Communications Biology (Dec 2022)
RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells
- Sho Sugawara,
- Ryo Okada,
- Tze Mun Loo,
- Hisamichi Tanaka,
- Kenichi Miyata,
- Masatomo Chiba,
- Hiroko Kawasaki,
- Kaoru Katoh,
- Shizuo Kaji,
- Yoshiro Maezawa,
- Koutaro Yokote,
- Mizuho Nakayama,
- Masanobu Oshima,
- Koji Nagao,
- Chikashi Obuse,
- Satoshi Nagayama,
- Keiyo Takubo,
- Akira Nakanishi,
- Masato T. Kanemaki,
- Eiji Hara,
- Akiko Takahashi
Affiliations
- Sho Sugawara
- Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research
- Ryo Okada
- Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research
- Tze Mun Loo
- Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research
- Hisamichi Tanaka
- Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research
- Kenichi Miyata
- Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research
- Masatomo Chiba
- Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research
- Hiroko Kawasaki
- Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research
- Kaoru Katoh
- Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
- Shizuo Kaji
- Institute of Mathematics for Industry, Kyushu University
- Yoshiro Maezawa
- Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba
- Koutaro Yokote
- Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba
- Mizuho Nakayama
- Division of Genetics, Cancer Research Institute, Kanazawa University
- Masanobu Oshima
- Division of Genetics, Cancer Research Institute, Kanazawa University
- Koji Nagao
- Laboratory of Genome Structure and Function, Graduated School of Science, Osaka University
- Chikashi Obuse
- Laboratory of Genome Structure and Function, Graduated School of Science, Osaka University
- Satoshi Nagayama
- Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research
- Keiyo Takubo
- Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine
- Akira Nakanishi
- Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)
- Masato T. Kanemaki
- Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Yata 1111, Mishima
- Eiji Hara
- Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita
- Akiko Takahashi
- Division of Cellular Senescence, Cancer Institute, Japanese Foundation for Cancer Research
- DOI
- https://doi.org/10.1038/s42003-022-04369-7
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
The levels of catalytic subunit of the RNaseH2 enzyme, RNAseH2A, decrease during senescence promoting nucleotide accumulation and a senescence-associated secretory phenotype.
