UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication

Mara Biasin; Andrea Bianco; Giovanni Pareschi; Adalberto Cavalleri; Claudia Cavatorta; Claudio Fenizia; Paola Galli; Luigi Lessio; Manuela Lualdi; Enrico Tombetti; Alessandro Ambrosi; Edoardo Maria Alberto Redaelli; Irma Saulle; Daria Trabattoni; Alessio Zanutta; Mario Clerici

doi:10.1038/s41598-021-85425-w

Scientific Reports (Mar 2021)

UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication

Mara Biasin,
Andrea Bianco,
Giovanni Pareschi,
Adalberto Cavalleri,
Claudia Cavatorta,
Claudio Fenizia,
Paola Galli,
Luigi Lessio,
Manuela Lualdi,
Enrico Tombetti,
Alessandro Ambrosi,
Edoardo Maria Alberto Redaelli,
Irma Saulle,
Daria Trabattoni,
Alessio Zanutta,
Mario Clerici

Affiliations

Mara Biasin: Department of Biomedical and Clinical Sciences L. Sacco, University of Milan
Andrea Bianco: Italian National Institute for Astrophysics (INAF)-Brera Astronomical Observatory
Giovanni Pareschi: Italian National Institute for Astrophysics (INAF)-Brera Astronomical Observatory
Adalberto Cavalleri: Epidemiology and Prevention Unit, IRCCS Foundation, Istituto Nazionale dei Tumori
Claudia Cavatorta: Epidemiology and Prevention Unit, IRCCS Foundation, Istituto Nazionale dei Tumori
Claudio Fenizia: Department of Biomedical and Clinical Sciences L. Sacco, University of Milan
Paola Galli: Italian National Institute for Astrophysics (INAF)-Brera Astronomical Observatory
Luigi Lessio: Italian National Institute for Astrophysics (INAF)-Padova Astronomical Observatory
Manuela Lualdi: Department of Imaging Diagnostic and Radioterapy, IRCCS Foundation, Istituto Nazionale dei Tumori
Enrico Tombetti: Department of Biomedical and Clinical Sciences L. Sacco, University of Milan
Alessandro Ambrosi: University Life and Health San Raffaele
Edoardo Maria Alberto Redaelli: Italian National Institute for Astrophysics (INAF)-Brera Astronomical Observatory
Irma Saulle: Department of Biomedical and Clinical Sciences L. Sacco, University of Milan
Daria Trabattoni: Department of Biomedical and Clinical Sciences L. Sacco, University of Milan
Alessio Zanutta: Italian National Institute for Astrophysics (INAF)-Brera Astronomical Observatory
Mario Clerici: Department of Pathophysiology and Transplantation, University of Milan

DOI: https://doi.org/10.1038/s41598-021-85425-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 7

Abstract

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Abstract The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm2 was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9 mJ/cm2. These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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