Scientific Reports (Apr 2025)
Fish consumption and gastric cancer within the Stomach cancer Pooling (StoP) Project
- Carlotta Franchi,
- Ilaria Ardoino,
- Sara Mandelli,
- Linia Patel,
- Claudio Pelucchi,
- Rossella Bonzi,
- M. Constanza Camargo,
- Charles S. Rabkin,
- Linda M. Liao,
- Rashmi Sinha,
- Kenneth C. Johnson,
- Jinfu Hu,
- Zuo-Feng Zhang,
- Domenico Palli,
- Monica Ferraroni,
- Eva Negri,
- Federica Turati,
- Guo-Pei Yu,
- Nuno Lunet,
- Samantha Morais,
- Lizbeth López-Carrillo,
- Shoichiro Tsugane,
- Akihisa Hidaka,
- Reza Malekzadeh,
- David Zaridze,
- Dmitry Maximovitch,
- Jesus Vioque,
- Sandra Gonzalez-Palacios,
- Mary H. Ward,
- Nuria Aragonés,
- Gemma Castaño-Vinyals,
- Maria Paula Curado,
- Emmanuel Dias-Neto,
- Gerson Shigueaki Hamada,
- Raul Ulises Hernández-Ramirez,
- Mohammadreza Pakseresht,
- Farhad Pourfarzi,
- Lina Mu,
- Areti Lagiou,
- Pagona Lagiou,
- Malaquias López-Cervantes,
- Alberto Dolci,
- Stefania Boccia,
- Roberta Pastorino,
- Paolo Boffetta,
- Barbara D’Avanzo,
- Carlo La Vecchia
Affiliations
- Carlotta Franchi
- Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS
- Ilaria Ardoino
- Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS
- Sara Mandelli
- Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS
- Linia Patel
- Branch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Università degli Studi di Milano
- Claudio Pelucchi
- Branch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Università degli Studi di Milano
- Rossella Bonzi
- Branch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Università degli Studi di Milano
- M. Constanza Camargo
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Charles S. Rabkin
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Linda M. Liao
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Rashmi Sinha
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Kenneth C. Johnson
- School of Epidemiology and Public Health, Department of Medicine, University of Ottawa
- Jinfu Hu
- Harbin Medical University
- Zuo-Feng Zhang
- Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center
- Domenico Palli
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO
- Monica Ferraroni
- Branch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Università degli Studi di Milano
- Eva Negri
- Branch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Università degli Studi di Milano
- Federica Turati
- Branch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Università degli Studi di Milano
- Guo-Pei Yu
- Medical Informatics Center, Peking University
- Nuno Lunet
- EPIUnit – Instituto de Saúde Pública da Universidade do Porto
- Samantha Morais
- EPIUnit – Instituto de Saúde Pública da Universidade do Porto
- Lizbeth López-Carrillo
- Mexico National Institute of Public Health
- Shoichiro Tsugane
- Division of Cohort Research, National Cancer Center Institute for Cancer Control
- Akihisa Hidaka
- Division of Epidemiology, National Cancer Center Institute for Cancer Control
- Reza Malekzadeh
- Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences
- David Zaridze
- Department of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology
- Dmitry Maximovitch
- Department of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology
- Jesus Vioque
- Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernandez (ISABIAL-UMH)
- Sandra Gonzalez-Palacios
- Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernandez (ISABIAL-UMH)
- Mary H. Ward
- Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Nuria Aragonés
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)
- Gemma Castaño-Vinyals
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)
- Maria Paula Curado
- Centro Internacional de Pesquisa, A. C. Camargo Cancer Center
- Emmanuel Dias-Neto
- Centro Internacional de Pesquisa, A. C. Camargo Cancer Center
- Gerson Shigueaki Hamada
- Nikkei Disease Prevention Center
- Raul Ulises Hernández-Ramirez
- Department of Biostatistics, Yale School of Public Health, Yale School of Medicine
- Mohammadreza Pakseresht
- Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences
- Farhad Pourfarzi
- Digestive Disease Research Center, Ardabil University of Medical Sciences
- Lina Mu
- Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo
- Areti Lagiou
- Department of Public and Community Health, School of Public Health, University of West Attica
- Pagona Lagiou
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens
- Malaquias López-Cervantes
- Facultad de Medicina, UNAM
- Alberto Dolci
- Research and Development Department, Bolton Food SpA
- Stefania Boccia
- Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore
- Roberta Pastorino
- Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore
- Paolo Boffetta
- Department of Medical and Surgical Sciences, University of Bologna
- Barbara D’Avanzo
- Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS
- Carlo La Vecchia
- Branch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Università degli Studi di Milano
- DOI
- https://doi.org/10.1038/s41598-025-96658-4
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 13
Abstract
Abstract Gastric cancer is among the most common cancer and cause of cancer death. We conducted a meta-analysis of 25 case–control studies from the Stomach cancer Pooling Project to assess the association between fish or canned fish consumption and the risk of gastric cancer. 10,431 cases and 24,903 controls were available. We found no association between fish consumption and risk of gastric cancer (pooled odds ratios (OR) = 0.99; 95% confidence interval (CI) 0.86–1.13, for at least one serving/week vs none). Geographical differences were found: in Asia an increased intake of fish was associated with a lower stomach cancer risk. In the sensitivity analyses, fish consumption was associated to a lower risk of gastric cancer in models adjusted for family history of gastric cancer (OR = 0.80, 95% CI 0.72–0.89) and Helicobacter Pylori infection (OR = 0.72, 95% CI 0.60–0.88), but not for body mass index or energy intake. Seven studies collected information on canned fish (4525 cases and 8073 controls). No association was found for canned fish (OR = 0.96, 95% CI 0.82–1.13). In conclusion, our results provide evidence that fish and canned fish intake are not associated with gastric cancer risk, although geographical differences have been highlighted, with a lower risk of gastric cancer in Asia.
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