Complex role of SIRT6 in NF-κB pathway regulation

Abstract

The NF-κB pathway regulates cell physiology under stress conditions. We have recently described a novel NF-κB regulatory mechanism, by which SIRT6 induces cysteine monoubiquitination of the methyltransferase SUV39H1. This causes SUV39H1 dissociation from the gene encoding the NF-κB inhibitor IκBα, increasing its expression and leading to NF-κB pathway inactivation.

Keywords

• sirt6
• nf-κb
• sirtuins, nad+
• iκbα
• suv39h1
• skp2