The effects of various streptokinase thrombolysis regimens on coagulation hemostasis and fibrinolysis in acute myocardial infarction

Abstract

Aim. To study effects of various streptokinase thrombolytic therapy (TLT) and following antithrombotic therapy variants on coagulation hemostasis and fibrinolysis parameters; to prove the opportunity to use reduced streptokinase doses in acute myocardial infarction (AMI) treatment. Material and methods. In total, 56 AMI patients received standard streptokinase dose, 1 500 000 U; 61 patients received reduced streptokinase dose, 750 000 U. In each group, thrombolysis was followed by various antithrombotic regimens. In all participants, coagulation hemostasis and fibrinolysis parameters were measured before TLT, 3 hours, 5, 10, and 20 days later. Results. Reduced streptokinase dose influenced coagulation hemostasis and fibrinolysis parameters similar to standard dose. No benefits for any special post-thrombolysis antithrombotic therapy regimen were registered in AMI patients. Conclusion. In AMI patients, reduced streptokinase doses could be used for TLT. After TLT, aspirin monotherapy can be recommended.

Keywords

• acute myocardial infarction
• streptokinase
• coagulation hemostasis
• fibrinolysis