Histological liver, kidney, and brain changes induced by pregabalin drug in albino rats

Abstract

Pregabalin is a commonly used medication for the treatment of pain associated with neuropathic conditions, but there has been little research on its harmful consequences. This study divided 20 adult male rats into two sets (I and II). I set was given distilled water (5 ml/kg, orally), while II set was given pregabalin (12.8 mg/kg, orally) for 30 consecutive days. The histological and immunohistochemical features of the brain were investigated. A histomorphometric analysis was also performed, and the rats' weights were determined. The results revealed a variety of histopathological lesions. There was a positive response for GFAP (glial fibrillary acidic protein) expression in the brain. There were histological lesions in the liver, kidney, and brain, as well as differences in the histomorphometric measurements in set II compared to set I. Meaningful elevations in the GOT/AST (aspartate aminotransferase), GPT/ALT (alanine aminotransferase), and creatinine levels were explored, but a non-significant increase in the urea amount was noticed. The medication caused a meaningful elevation in body weight. The results revealed that the drug has toxic effects on the vital organs and their functions and can change their cellular structure if taken for a long time. Therefore, considering its side effects, it must be taken under medical advice.

Keywords

• gfap
• anticonvulsive
• necrosis
• degeneration