Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs

Quentin R. V. Ferry; Radostina Lyutova; Tudor A. Fulga

doi:10.1038/ncomms14633

Nature Communications (Mar 2017)

Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs

Quentin R. V. Ferry,
Radostina Lyutova,
Tudor A. Fulga

Affiliations

Quentin R. V. Ferry: Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford
Radostina Lyutova: Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford
Tudor A. Fulga: Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford

DOI: https://doi.org/10.1038/ncomms14633
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Being able to regulate gene expression in a controllable manner is one of the promises of synthetic biology, and CRISPR-Cas9 is one of the tools being developed to achieve that goal. Here the authors develop an inducible CRISPR platform using an engineered guide RNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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