Frontiers in Pharmacology (Jan 2022)

Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion

  • Lipeng Tang,
  • Lipeng Tang,
  • Lipeng Tang,
  • Tong Li,
  • Tong Li,
  • Tong Li,
  • Tong Li,
  • Bowen Zhang,
  • Zihao Zhang,
  • Xiaoyi Sun,
  • Ying Zhu,
  • Ying Zhu,
  • Ying Zhu,
  • Bing Feng,
  • Bing Feng,
  • Bing Feng,
  • Zuqing Su,
  • Zuqing Su,
  • Zuqing Su,
  • Laijun Yang,
  • Hongxia Li,
  • Huazhen Liu,
  • Yuchao Chen,
  • Zhenhua Dai,
  • Xirun Zheng,
  • Mingxian Li,
  • Chutian Li,
  • Jie Zhao,
  • Xinmin Qiu,
  • Shuyan Ye,
  • Han Liu,
  • Guangjuan Zheng,
  • Guangjuan Zheng,
  • Guangjuan Zheng,
  • Guangjuan Zheng,
  • Ben Li,
  • Chuanjian Lu,
  • Chuanjian Lu,
  • Chuanjian Lu,
  • Chuanjian Lu

DOI
https://doi.org/10.3389/fphar.2022.817526
Journal volume & issue
Vol. 13

Abstract

Read online

Psoriasis is a chronic and inflammatory skin disorder characterized by inflammation and epidermal hyperplasia. Punicalagin (PUN) is a main active ingredient of pomegranate (Punica granatum L.) peel with multiple biological activities, such as antibacterial, antioxidant and anti-tumor effects. However, the potential effect of PUN on psoriasis remains unknown. In this study, we want to investigate the pharmacological effect of PUN on psoriasis by using imiquimod (IMQ)-induced psoriatic mice model in vivo and tumor necrosis factor a (TNF-α) and interleukin-17A (IL-17A)-stimulated HaCaT cells in vitro. Our results showed that PUN can effectively alleviate the severity of psoriasis-like symptoms. Mechanistically, PUN potently suppresses the aberrant upregulation of interleukin-1β (IL-1β) and subsequent IL-1β-mediated inflammatory cascade in keratinocytes by inhibiting the nuclear factor kappa B (NF-κB) activation and cleaved caspase-1 expression in vitro and in vivo. Taken together, our findings indicate that PUN can relieve psoriasis by repressing NF-κB-mediated IL-1β transcription and caspase-1-regulated IL-1β secretion, which provide evidence that PUN might represent a novel and promising candidate for the treatment of psoriasis.

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