Nature Communications (Mar 2023)
Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression
- Frederic Li Mow Chee,
- Bruno Beernaert,
- Billie G. C. Griffith,
- Alexander E. P. Loftus,
- Yatendra Kumar,
- Jimi C. Wills,
- Martin Lee,
- Jessica Valli,
- Ann P. Wheeler,
- J. Douglas Armstrong,
- Maddy Parsons,
- Irene M. Leigh,
- Charlotte M. Proby,
- Alex von Kriegsheim,
- Wendy A. Bickmore,
- Margaret C. Frame,
- Adam Byron
Affiliations
- Frederic Li Mow Chee
- Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh
- Bruno Beernaert
- Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh
- Billie G. C. Griffith
- Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh
- Alexander E. P. Loftus
- Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh
- Yatendra Kumar
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh
- Jimi C. Wills
- Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh
- Martin Lee
- Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh
- Jessica Valli
- Edinburgh Super Resolution Imaging Consortium, Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University
- Ann P. Wheeler
- Advanced Imaging Resource, Institute of Genetics and Cancer, University of Edinburgh
- J. Douglas Armstrong
- Simons Initiative for the Developing Brain, School of Informatics, University of Edinburgh
- Maddy Parsons
- Randall Centre for Cell and Molecular Biophysics, King’s College London
- Irene M. Leigh
- Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee
- Charlotte M. Proby
- Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee
- Alex von Kriegsheim
- Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh
- Wendy A. Bickmore
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh
- Margaret C. Frame
- Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh
- Adam Byron
- Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-023-37021-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene expression.
