Explanation of the cell orientation in a nanofiber membrane by the geometric potential theory

Abstract

Cell orientation plays an important role in tissue engineering, and many experiments showed that aligned nanofibers have a good guide for cell orientation, but its biomechanism is not clear. Here we show that the capillary-like effect or more accurately the geometric potential theory can explain the phenomenon. Keywords: Cell orientation, Nanofiber substrate, Geometric potential, Fiber orientation