Genotoxicity and mutagenicity of inosine pranobex

Tobólska Sylwia; Terpiłowska Sylwia; Jaroszewski Jerzy; Siwicki Andrzej Krzysztof

doi:10.2478/jvetres-2018-0030

Journal of Veterinary Research (Jul 2018)

Genotoxicity and mutagenicity of inosine pranobex

Tobólska Sylwia,
Terpiłowska Sylwia,
Jaroszewski Jerzy,
Siwicki Andrzej Krzysztof

Affiliations

Tobólska Sylwia: Vet-Agro, 20-616Lublin, Poland
Terpiłowska Sylwia: Laboratory of Environmental Biology, Institute of Environmental Engineering, The John Paul II Catholic University of Lublin, 20-950Lublin, Poland
Jaroszewski Jerzy: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957Olsztyn, Poland
Siwicki Andrzej Krzysztof: Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957Olsztyn, Poland

DOI: https://doi.org/10.2478/jvetres-2018-0030
Journal volume & issue: Vol. 62, no. 2
pp. 207 – 213

Abstract

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Inosine pranobex (Methisoprinol, ISO, Isoprinosine) is an immuno-modulatory antiviral drug that has been licensed since 1971 in several countries worldwide. In humans, the drug is approved for the treatment of viral infections, and it might also have therapeutic use in animals. The aims of the presented work were to investigate the genotoxicity of inosine pranobex on BALB/3T3 clone A1 and HepG2 cell lines and to elucidate its mutagenicity using the Ames test.

Published in Journal of Veterinary Research

ISSN: 2450-8608 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Agriculture: Animal culture: Veterinary medicine
Website: https://sciendo.com/journal/JVETRES

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