Rare life threatening reactions to both propofol and sevoflurane in a patient with an undiagnosed myopathy: a case report.

Abstract

Propofol infusion syndrome (PRIS) and anesthesia-in- duced rigidity (AIR) are both rare complications reported in the literature. This report describes a patient with a pre- viously undiagnosed myopathy (MYH7) that had severe adverse reactions, although different in nature, to both propofol and sevoflurane. The patient was a 4 month old caucasian female with prenatally diagnosed DORV, a subaortic VSD, and a secundum ASD who presented for complete repair of her CHD. This report details her hos- pital course and outcomes with a brief review of the lit- erature that is pertinent to her case. Myosin heavy chain (MYH7)-related myopathies are emerging as an important group of muscle diseases of childhood and adulthood. Precautions must be taken when using either inhalational anesthesia or TIVA (total intravenous anes- thesia) with propofol.

Keywords

• propofol infusion syndrome (pris)
• anesthesia-induced rigidity (air)
• myopathy
• children
• inhaled anesthetics