Nature Communications (Aug 2022)

Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

  • Guillermo Barturen,
  • Elena Carnero-Montoro,
  • Manuel Martínez-Bueno,
  • Silvia Rojo-Rello,
  • Beatriz Sobrino,
  • Óscar Porras-Perales,
  • Clara Alcántara-Domínguez,
  • David Bernardo,
  • Marta E. Alarcón-Riquelme

DOI
https://doi.org/10.1038/s41467-022-32357-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

Genetic associations with severe COVID-19 have been discovered, but epigenetic associations are not as well described. Here, the authors perform a genome-wide epigenetic analysis of COVID-19 patients, discovering an interaction between environmental exposure, genetics, and epigenetics which might play a role in severe disease.