Nature Communications (May 2021)
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
- Kerstin Renner,
- Tobias Schwittay,
- Sophia Chaabane,
- Johanna Gottschling,
- Christine Müller,
- Charlotte Tiefenböck,
- Jan-Niklas Salewski,
- Frederike Winter,
- Simone Buchtler,
- Saidou Balam,
- Maximilian V. Malfertheiner,
- Matthias Lubnow,
- Dirk Lunz,
- Bernhard Graf,
- Florian Hitzenbichler,
- Frank Hanses,
- Hendrik Poeck,
- Marina Kreutz,
- Evelyn Orsó,
- Ralph Burkhardt,
- Tanja Niedermair,
- Christoph Brochhausen,
- André Gessner,
- Bernd Salzberger,
- Matthias Mack
Affiliations
- Kerstin Renner
- Department of Nephrology, University Hospital Regensburg
- Tobias Schwittay
- Department of Nephrology, University Hospital Regensburg
- Sophia Chaabane
- Department of Nephrology, University Hospital Regensburg
- Johanna Gottschling
- Department of Nephrology, University Hospital Regensburg
- Christine Müller
- Department of Nephrology, University Hospital Regensburg
- Charlotte Tiefenböck
- Department of Nephrology, University Hospital Regensburg
- Jan-Niklas Salewski
- Department of Nephrology, University Hospital Regensburg
- Frederike Winter
- Department of Nephrology, University Hospital Regensburg
- Simone Buchtler
- Department of Nephrology, University Hospital Regensburg
- Saidou Balam
- Department of Nephrology, University Hospital Regensburg
- Maximilian V. Malfertheiner
- Department of Internal Medicine II, University Hospital Regensburg
- Matthias Lubnow
- Department of Internal Medicine II, University Hospital Regensburg
- Dirk Lunz
- Department of Anesthesiology, University Hospital Regensburg
- Bernhard Graf
- Department of Anesthesiology, University Hospital Regensburg
- Florian Hitzenbichler
- Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg
- Frank Hanses
- Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg
- Hendrik Poeck
- Department of Internal Medicine III, University Hospital Regensburg
- Marina Kreutz
- Department of Internal Medicine III, University Hospital Regensburg
- Evelyn Orsó
- Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg
- Ralph Burkhardt
- Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg
- Tanja Niedermair
- Institute of Pathology, University of Regensburg
- Christoph Brochhausen
- Institute of Pathology, University of Regensburg
- André Gessner
- Institute Clinical Microbiology and Hygiene, University Hospital Regensburg
- Bernd Salzberger
- Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg
- Matthias Mack
- Department of Nephrology, University Hospital Regensburg
- DOI
- https://doi.org/10.1038/s41467-021-23334-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Perturbed T cell responses and disturbed cytokine secretion have been shown during SARS-CoV2 infection in patients. Here the authors show reduced polyclonal T cell activity in COVID-19 patients that is caused by plasma factors and linked to poor prognosis and viral persistence.
