Cellular Physiology and Biochemistry (Jan 2015)

Pamidronate Attenuates Diastolic Dysfunction Induced by Myocardial Infarction Associated with Changes in Geometric Patterning

  • Andréa F. Gonçalves,
  • Luiz Henrique Congio,
  • Priscila P. dos Santos,
  • Bruna P. M. Rafacho,
  • Bruna L. B. Pereira,
  • Renan F. T. Claro,
  • Nara A. Costa,
  • Fernanda Chiuso-Minicucci,
  • Paula S. Azevedo,
  • Bertha F. Polegato,
  • Katashi Okoshi,
  • Elenize J. Pereira,
  • Marina P. Okoshi,
  • Sergio A. R. Paiva,
  • Leonardo A. M. Zornoff,
  • Marcos F. Minicucci

DOI
https://doi.org/10.1159/000369693
Journal volume & issue
Vol. 35, no. 1
pp. 259 – 269

Abstract

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Background/Aims: The aim of this study was to evaluate the influence of pamidronate on ventricular remodeling after myocardial infarction. Methods: Male Wistar rats were assigned to four groups: a sham group, in which animals were submitted to simulated surgery and received weekly subcutaneous injection of saline (S group; n=14); a group in which animals received weekly subcutaneous injection of pamidronate (3 mg/kg of body weight) and were submitted to simulated surgery (SP group, n=14); a myocardial infarction group, in which animals were submitted to coronary artery ligation and received weekly subcutaneous injection of saline (MI group, n=13); and a myocardial infarction group with pamidronate treatment (MIP group, n=14). The rats were observed for three months. Results: Animals submitted to MI had left chamber enlargement and worse diastolic and systolic function compared with SHAM groups. E/A ratio, LV posterior and relative wall thickness were lower in the MIP compared with the MI group. There was no interaction between pamidronate administration and MI on systolic function, myocyte hypertrophy, collagen content, and calcium handling proteins. Conclusion: Pamidronate attenuates diastolic dysfunction following MI.

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