Nature Communications (Mar 2022)
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
- Jia Duan,
- Dan-Dan Shen,
- Tingting Zhao,
- Shimeng Guo,
- Xinheng He,
- Wanchao Yin,
- Peiyu Xu,
- Yujie Ji,
- Li-Nan Chen,
- Jinyu Liu,
- Huibing Zhang,
- Qiufeng Liu,
- Yi Shi,
- Xi Cheng,
- Hualiang Jiang,
- H. Eric Xu,
- Yan Zhang,
- Xin Xie,
- Yi Jiang
Affiliations
- Jia Duan
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Dan-Dan Shen
- Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou
- Tingting Zhao
- School of Chinese Materia Medica, Nanjing University of Chinese Medicine
- Shimeng Guo
- School of Chinese Materia Medica, Nanjing University of Chinese Medicine
- Xinheng He
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Wanchao Yin
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Peiyu Xu
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Yujie Ji
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Li-Nan Chen
- Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou
- Jinyu Liu
- School of Chinese Materia Medica, Nanjing University of Chinese Medicine
- Huibing Zhang
- Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou
- Qiufeng Liu
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Yi Shi
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Xi Cheng
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Hualiang Jiang
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- H. Eric Xu
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Yan Zhang
- Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou
- Xin Xie
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Yi Jiang
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-022-29072-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
The basis for the diverse peptide-binding modes and the G protein selectivity of peptide GPCRs remains elusive. Here, the authors offer a structural basis for allosteric-like agonism and G protein selectivity of a neuropeptide GPCR, galanin receptor.
