Effect of varying levels of Glycemia on CA-19.9

Abstract

Objective: To compare differences in CA-19.9 levels among participants with and without Type 2 diabetes mellitus and to correlate increasing glycemia levels and HbA1c with CA-19.9 Study Design: Comparative cross-sectional study Place and Duration of Study: Department of Chemical Pathology, Combined Military Hospital, Multan Pakistan, from Feb to Aug 2022. Methodology: One hundred thirty-one patients with diabetes and without diabetes were enrolled. CA-19.9, fasting plasma glucose, HbA1c, amylase, lipase, and anthropometric parameters were assessed. Patients with diabetes were divided into three groups based on FPG and HbA1c levels to investigate the relationship between CA-19.9 and glycemic status. Results: There was no significant difference among CA-19.9 of Controls and patients with diabetes (19.45±14.89 versus 15.83±13.98, p=0.155). FPG and HbA1c showed a moderate positive correlation to CA-19.9 (r = 0.283, p= 0.001 and r= = 0.305, p7.0% (p=0.020), HbA1c 7.0%(p=0.037) and with increasing FPG in groups with FPG 5.6-7.0 mmol/L Vs >7.0 mmol/L (p=0.005). Conclusion: The glycemic status of patients with diabetes can influence their serum CA-19.9 levels, and glycemic control should be considered while interpreting these levels in such patients. T2DM patients with poor glycemic control have a higher CA of 19.9 than those with better control.

Keywords

• CA-19.9
• Fasting plasma glucose
• HbA1c
• Type-2 Diabetes Mellitus