Nature Communications (Jan 2023)
The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators
- Lisa-Marie Appel,
- Vedran Franke,
- Johannes Benedum,
- Irina Grishkovskaya,
- Xué Strobl,
- Anton Polyansky,
- Gregor Ammann,
- Sebastian Platzer,
- Andrea Neudolt,
- Anna Wunder,
- Lena Walch,
- Stefanie Kaiser,
- Bojan Zagrovic,
- Kristina Djinovic-Carugo,
- Altuna Akalin,
- Dea Slade
Affiliations
- Lisa-Marie Appel
- Department of Radiation Oncology, Medical University of Vienna
- Vedran Franke
- The Berlin Institute for Medical Systems Biology, Max Delbrück Center
- Johannes Benedum
- Department of Radiation Oncology, Medical University of Vienna
- Irina Grishkovskaya
- Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna Biocenter
- Xué Strobl
- Department of Medical Biochemistry, Medical University of Vienna, Max Perutz Labs, Vienna Biocenter
- Anton Polyansky
- Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna Biocenter
- Gregor Ammann
- Department of Pharmaceutical Chemistry, Goethe University Frankfurt
- Sebastian Platzer
- Department of Medical Biochemistry, Medical University of Vienna, Max Perutz Labs, Vienna Biocenter
- Andrea Neudolt
- Department of Medical Biochemistry, Medical University of Vienna, Max Perutz Labs, Vienna Biocenter
- Anna Wunder
- Department of Medical Biochemistry, Medical University of Vienna, Max Perutz Labs, Vienna Biocenter
- Lena Walch
- Department of Medical Biochemistry, Medical University of Vienna, Max Perutz Labs, Vienna Biocenter
- Stefanie Kaiser
- Department of Pharmaceutical Chemistry, Goethe University Frankfurt
- Bojan Zagrovic
- Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna Biocenter
- Kristina Djinovic-Carugo
- Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Vienna Biocenter
- Altuna Akalin
- The Berlin Institute for Medical Systems Biology, Max Delbrück Center
- Dea Slade
- Department of Radiation Oncology, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s41467-023-35853-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 22
Abstract
Here the authors establish the SPOC domain as a universal reader of the RNA Pol II CTD code and a versatile reader of phosphoserine marks found in co- and post-transcriptional regulators such as m6A writer and reader proteins.
