Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus

Henrique Machado; Yara Seif; George Sakoulas; Connor A. Olson; Ying Hefner; Amitesh Anand; Ying Z. Jones; Richard Szubin; Bernhard O. Palsson; Victor Nizet; Adam M. Feist

doi:10.1038/s42003-021-02339-z

Communications Biology (Jun 2021)

Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus

Henrique Machado,
Yara Seif,
George Sakoulas,
Connor A. Olson,
Ying Hefner,
Amitesh Anand,
Ying Z. Jones,
Richard Szubin,
Bernhard O. Palsson,
Victor Nizet,
Adam M. Feist

Affiliations

Henrique Machado: Department of Bioengineering, University of California San Diego
Yara Seif: Department of Bioengineering, University of California San Diego
George Sakoulas: Collaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California San Diego
Connor A. Olson: Department of Bioengineering, University of California San Diego
Ying Hefner: Department of Bioengineering, University of California San Diego
Amitesh Anand: Department of Bioengineering, University of California San Diego
Ying Z. Jones: Department of Cellular and Molecular Medicine, University of California San Diego
Richard Szubin: Department of Bioengineering, University of California San Diego
Bernhard O. Palsson: Department of Bioengineering, University of California San Diego
Victor Nizet: Collaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California San Diego
Adam M. Feist: Department of Bioengineering, University of California San Diego

DOI: https://doi.org/10.1038/s42003-021-02339-z
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Henrique Machado et al. describe mutational mechanisms associated with MRSA vancomycin resistance in Staphylococcus aureus using adaptive laboratory evolution experiments focused on tolerance. Their results reveal environment-dependent mutational strategies to vancomycin tolerization and the impact of mutations in regulatory genes, providing insight into the development of antibiotic resistance under multiple conditions.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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