Communications Biology (Nov 2021)
Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice
- Eriko Nakamura,
- Kenji Hata,
- Yoshifumi Takahata,
- Hiroshi Kurosaka,
- Makoto Abe,
- Takaya Abe,
- Miho Kihara,
- Toshihisa Komori,
- Sachi Kobayashi,
- Tomohiko Murakami,
- Toshihiro Inubushi,
- Takashi Yamashiro,
- Shiori Yamamoto,
- Haruhiko Akiyama,
- Makoto Kawaguchi,
- Nobuo Sakata,
- Riko Nishimura
Affiliations
- Eriko Nakamura
- Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
- Kenji Hata
- Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
- Yoshifumi Takahata
- Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
- Hiroshi Kurosaka
- Department of Orthodontics and Dentofacial Orthopedics, Osaka University Graduate School of Dentistry
- Makoto Abe
- Department of Oral Anatomy and Developmental Biology, Osaka University, Graduate School of Dentistry
- Takaya Abe
- Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research
- Miho Kihara
- Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research
- Toshihisa Komori
- Basic and Translational Research Center for Hard Tissue Disease, Nagasaki University Graduate School of Biomedical Sciences
- Sachi Kobayashi
- Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
- Tomohiko Murakami
- Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
- Toshihiro Inubushi
- Department of Orthodontics and Dentofacial Orthopedics, Osaka University Graduate School of Dentistry
- Takashi Yamashiro
- Department of Orthodontics and Dentofacial Orthopedics, Osaka University Graduate School of Dentistry
- Shiori Yamamoto
- Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
- Haruhiko Akiyama
- Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine
- Makoto Kawaguchi
- Division of Diagnostic Pathology, Niigata Rosai Hospital, Japan Organization of Occupational Health and Safety
- Nobuo Sakata
- Department of Biochemistry, Showa Pharmaceutical University, Machida
- Riko Nishimura
- Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
- DOI
- https://doi.org/10.1038/s42003-021-02793-9
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 11
Abstract
Nakamura et al. used expression studies to identify an enrichment of Zfhx4 in cartilage and revealed through global gene knock-down that it is required for proper endochondral ossification in mice. They further demonstrated a physical and genetic interaction between Zfhx4 and Osterix, which is of interest to the field of transcriptional regulation of mammalian endochondral ossification.
